Endocannabinoid vs Exocannabinoid Article

What is an Exocannabinoid 

 In the rapidly progressive world of cannabis, there are always new interesting discoveries. In this article, you'll get a closer look at within the well oiled machine that is the cannabis plant. Specifically, Endocannabinoids & Exocannabinoids. 


 Starting with Endocannabinoids:

 The Endocannabinoid system consists of two receptors known as G-protein coupled receptors, more commonly known as the CB1 & CB2 receptor. Endocannabinoids also consist of ligands & enzymes that regulate the levels of the endocannabinoids themselves.


Second, we have our Exocannabinoids:

 An Exocannabinoid is described in one of two forms; the first of the two are Phyto cannabinoids (meaning from the plant). Of you've ever consumed THC, CBD or the likes, you may already be familiar with these Phyto cannabinoids. Our second Exocannabinoids actually happen to be man-made Synthetic Cannabinoids. These synthetic Cannabinoids such as K2 or "spice" can be extremely harmful to both the body & mind. We here at Well Fed Wolf do not advocate for the use of Synthetic Cannabinoids, as we are a strictly natural wellness brand. 


 Regardless of whether it's natural or man-made, all Exocannabinoids are processed within Endocannabinoid system. How? Each cannabinoid binds to either the CB1 or CB2 (sometimes both) receptors! Each Exocannabinoid will have their own separate cause & effect depending on which receptor the cannabinoid is processed through within the Endocannabinoid system.


For example, THC (a Phyto cannabinoid) is an agonist of Both CB1 & CB2 receptors, however the "high" as some call it, is primarily occurring within the CB1 receptor (located within the brain & G-Protein-coupled receptors), but THC will also be processed in small amounts through our CB2 receptors (which are located within fatty tissue & different parts of the nervous system).

How amazing are these systems and the capacity for wellness showing is immense and ever expanding. 




 www.frontiersin.org, frontiers, accessed July 18th, 2022, "Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors"

 Endocannabinoid picture , by Justin Nguyen




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